There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. IMO routine blood pressures are a lacking All dogs start out with a once-daily dose of two 1 mg Incurin tablets regardless of body weight. prnpharmacal.com/products/urinary-health/proin-er. WebProven effective in reducing or eliminating urinary incontinence. Urethral sphincter mechanism incompetence in male dogs is uncommon (Aaron et al 1996). Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. J. small Anim. Yau WP, Mitchell AA, Lin KJ, et al. Hanson KR, Ware WA. Skip to The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. Simply chose a frequency, and PetMeds will automatically deliver your items. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Incurin: New FDA Approved Drug for Urinary Incontinence. Possible side effects have included signs of estrus (in heat), swollen vulva/teats and nausea. Rare side effects may include vaginal bleeding and hair loss. You should consult your veterinarian if you notice any side effects and keep all follow-up appointments. Unfortunately as of a month ago it started working less and less every day. Congenital urethral sphincter mechanism incompetence tends to be a problem of large breeds of dog, predominantly bitches. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. I am a bot, and this action was performed automatically. Press J to jump to the feed. Unfortunately as of a month ago it I guess I meant when . with Rainey, she started urinating (and defecating) whenever we'd leave -- even if it was just for 40 minutes. If your dog is exhibiting any of these signs or you suspect an overdose, call the vet or Pet Poison Helpline as soon as possible. The introduction of urethral pressure profilometry as an investigative aid in the bitch has allowed confirmation of the belief that poor urethral tone is implicated in urinary incontinence due to sphincter mechanism incompetence. 15% discount available for new customers only. Vet Rec. Proven effective in reducing or eliminating urinary incontinence, 93% of dogs treated were improved or continent by 6 weeks, One simple starting dose for all female dogs and just 1 tablet size to stock. Heartgard for Dogs: How it Works and What it Does? Short receptor binding time limits estrogen-related side effects. I am considering the compounding pharmacies as an option but it seems like the Incurin may be ok after all. Urology. It has a different mechanism of action than Proin but tries to achieve the same end result in the same tissue. I will make a note of both of those and save them in my bookmarks :-). In addition to these common adverse reactions, some dogs develop more serious side effects, such as tremors, seizures, collapse, stroke-like symptoms (loss of coordination, abnormal gait, inability to walk), elevated liver enzymes, blood in urine, urinary retention, and kidney failure. They did their tests and came back with the same conclusion. Clark JH, Markaverich BM. Urol Int. U.S. Food and Drug Administration Center for Veterinary Medicine. 69.163.186.88 Am J Epidemiol. Keep in mind that the info in this article is purely educational. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression.4 In the authors experience, therapy with estrogen-based products, such as estriol (Incurin; Merck Animal Health, merck-animal-health-usa.com), is preferable for patients with known behavioral concerns. 9. Proin is an FDA-approved drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. Accessed October 2020. WebIncurin Tablets vs. Proin Comparison | PetMeds FREE Standard Shipping EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products Our expert panel consists of DES is no longer available commercially. For the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs. ADVERSE REACTIONS: Mild, oestrogenic effects such as swollen vulva, swollen teats and/or attractiveness for males have been observed at the high dose of 2 mg. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). In talking to the vet office, they dont put dogs are both - their policy not specific to my dog. There were no estriol-related changes on bone marrow smears evaluated microscopically from dogs in the 10 mg (5X) group. Several drug interactions are possible. Vet. U.S. Food and Drug Administration. All rights reserved. It's off the human market. Currently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, Vtoquinol). Part 1: significance, clinical aspects and etiopathogenesis [in German]. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. I think i am leaning towards the DES so far, but i have yet to ask my vet about that one. Since Proin increases thirst, make sure your dog has ample fresh water within easy reach while supplementing. 9th ed. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). It is a multi-factorial problem and a variety of factors are known or suspected to contribute to its clinical manifestation of urinary incontinence. 2. Peter E. Holt, BVMS, PhD, ILTM, DECVS, CBiol, FIBiol, FRCVS I found this site with info about Incurin in Europe. We really want to switch her over to something new and our vet recently suggested Incurin. 16. Seems to do well for those I know that take it. An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. Click to reveal 1979;49:4665. It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP). Yes, you can give your dog Proin for control of urinary incontinence. However, after the FDA approval, the same active ingredient is also used in tablets for oral use made for dogs like Proin ER (phenylpropanolamine hydrochloride extended-release), which are made by Pegasus Laboratories. The dose of Incurin is not dependent upon body weight. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. 7. Someone in my fb group sent me this article which i found pretty helpful: http://www.leospetcare.com/incurin-estriol-is-not-the-same-as-ovaban-des/ (besides the fact that it says DES is no longer available). Performance & security by Cloudflare. 125, 478-480. Your previous content has been restored. in dogs having had the ovaries and uterus removed surgically). Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. The active ingredient in Incurin, estriol, is a naturally occurring, short-acting estrogen. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. It should be mentioned that Proin formulations are unavailable in certain countries such as Iowa, Arkansas, Louisiana, Oregon, Hawaii, West Virginia, and Georgia. Annu Rev Physiol. The active ingredient Phenylpropanolamine (PPA) can be found in human formulations (Proin, Uriflex-PT Propalin, Cystolamine, Uricon), which in veterinary medicine are used off-label. comments sorted by Best Top New Controversial Q&A . Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes. Two new products are now available for veterinarians working to control urinary incontinence in canines. Her research and clinical interests include urinary incontinence and lower urinary tract disease in dogs and cats. 2. After the initial load we only had to give her one pill a week, which is hardly anything. For additional information, please see theproduct label. Thank you. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. Compare Incurin Tablets vs. Proin ER with a detailed product breakdown. J. Vet. Res. 1984;20(4B):10051013.1. 5. Aust Vet J. We would just distract her in the other room while the other one discreetly cleaned up. WebThe use of Incurin is contraindicated during pregnancy, lactation and in animals younger than 1 year. Gynecol Obstet Invest. 3. NADA 141-324. Copyright 2023 PetMed Express, Inc. All Rights Reserved. It's an estrogen supplement similar to DES, but shorter acting so it has to be given daily. Hormones, particularly sex hormones, can influence vesico-urethral function and so may be implicated in sphincter mechanism incompetence. She does not pee in the crate when I'm at work. With Proin it has largely been a non issue. Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt, P.E. Also, do you know why it may be safer than DES? But the fact that it has been used in Europe makes me feel a little better - i wonder how long it has been on the market over there for? PRN Pharmacal. U.S. Food and Drug Administration Center for Veterinary Medicine. All natural. Paste as plain text instead, Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). 10. Problem is without the proin this is like a faucet right now. Proin chewable tablets. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. WebCurrently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, 5. We now have a prescription for DES. Dogs should not receive more than 2 mg of Incurin per day (2 tablets). By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Dogs with urinary tract infections (masks the signs). Flexible -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter. I know not to use Proin. Through phone tag with his office, he gave us a prescription for incurin to try as well as refilled our proin prescription. Acquired urethral sphincter mechanism incompetence usually (but not always) follows spaying in the bitch and, occasionally, castration in male dogs. Effect of combined treatment with phenylpropanolamine and estriol, compared with estriol treatment alone, in postmenopausal women with stress urinary incontinence. In extra sensitive dogs, Proin may trigger an allergic reaction with symptoms like hives, facial swelling (lips, tongue), and breathing difficulties. Took her in for a lot of tests and the vet came back with older fixed female dogs have this problem some times and prescribed her proin. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. What is your experience using either? Willow (Wilma Waggle), Wiki (Wiki Hard Ten), Carter (Let's Get It On), Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice. In addition, bulk estriol It was FDA approved over a year ago, but just became available this month. 12. 2001;149(25):764-767. Maybe you could try it. Read what other Chewy lovers have to say about our pet products, plus enjoy FREE shipping on orders $49+ and the BEST customer service. Flexible Affected spayed bitches may respond well to oestrogen therapy but in some animals the response ceases eventually, despite increasing the dosage of oestrogens, possibly due to desensitisation of oestrogen receptors. DES and incurin are given at different frequencys . Since, the safe use of Proin in breeding dogs, pregnant and lactating females is not evaluated, it is best not to use the medication in these situations and avoid potential side effects. Please see theproduct labelfor full prescribing information. Forsee KM, Davis GJ, Mouat EE, et al. Gilbert-Barness E, Drut RM. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. Oestrogens are contra-indicated in juvenile bitches with this condition because of possible adverse 'feedback' effects on the pituitary but alpha-adrenergics such as phenylpropanolamine could be used, pending oestrus. Ahlstrm K, Sandahl B, Sjberg B, et al. Phenylpropanolamine is effective at improving continence in dogs with USMI. Hamaide AJ, Grand JG, Farnir F, et al. 4. Kim and Bruce- with Rick (Rick Roufus 6/30/16) and missing my sweet greyhound Angels Rainey (LG's Rainey 10/4/2000 - 3/8/2011), Anubis (RJ's Saint Nick 12/25/2001 - 9/12/12) and Zeke (Hey Who Whiz It 4/6/2009 - 7/20/2020) and Larry (PTL Laroach 2/24/2007 - 8/2/2020) -- and Chester (Lab) (8/31/1990 - 5/3/2005), Captain (Schipperke) (10/12/1992 - 6/13/2005) and Remy (GSP) (?/?/1998 - 1/6/2005) at the bridge, "Always do sober what you said you'd do drunk. The proportion of dogs achieving treatment success was statistically significantly greater (p = 0.0038) in the group treated with INCURIN Tablets (66%) than I'm glad you are not going to use the proin--it's hard to say if your hound is hypertensive without taking pressures. 6. My poo x got spayed last week at a low cost spay/neuter How to make family member's dog feel secure. Reddit and its partners use cookies and similar technologies to provide you with a better experience. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. Diapers are off. Medical therapy of urinary incontinence in ovariectomised bitches: a comparison of the effectiveness of diethylstilboestrol and pseudoephedrine. So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. Incurin is indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized dogs. Byron JK, March PA, Chew DJ, DiBartola SP. While we provide information resources and canine education, the content here is not a substitute for veterinary guidance. Incurin for Dogs. Nol S, Cambier C, Baert K, et al. Were sorry, but our website doesnt work properly without JavaScript enabled. Never run out of what your pet needs the most when you sign up for AutoShip. I think the Incurin will be a good option. A treatment for female canine urinary incontinence that contains estriol, a naturally occurring, short-acting estrogen found in female dogs with the convenience of once-a-day dosing. Some limitations and restrictions may apply. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. During the procedure, the vagina is stretched cranially and anchored on either side of the urethra to the prepubic tendon. 127, 537-542. Dr. Byron is a clinical professor in the department of veterinary clinical sciences at the Ohio State University (OSU) College of Veterinary Medicine. You cannot paste images directly. Pasted as rich text. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). A place where you can ask veterinary medicine related questions and get advice from veterinary professionals. Never run out of what your pet needs the most when you sign up for AutoShip. Do not give OP specific treatment instructions, including instructions on meds and dosages. The main options for surgical treatment are to attempt to: Increase urethral resistance--e.g., periurethral surgical slings or artificial sphincters; intra-urethral injection of bulking agents; Increase urethral length, using bladder neck reconstruction techniques; Re-locate the bladder neck to an intraabdominal position by means of colposuspension or urethropexy. Vet J. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. Accessed October 2020. Upload or insert images from URL. Vet. You can email the site owner to let them know you were blocked. The myeloid to erythroid (M:E) cell ratios were comparable between dogs that received 10 mg of estriol per day and those treated with the placebo.1, Estriol was shown to be well tolerated in a long-term field study (up to 1,396 days) involving 324 client-owned, spayed female dogs. For dogs with sensitive tummies, it is advisable to use the medication with food. If you are going to pursue looking for DES Wedgewood Compounding Pharmacy has made it up for our clinic recently-made it into a chicken flavored chewable tablet. Formulations that are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Proin Drops. Incurin (estriol) Tablets have been proven to reduce or eliminate urinary incontinence in spayed female dogs.1, Incurin helps restore urinary continenceThe majority of owners participating in a study of over 200 subjects felt their dogs improved after being treated with Incurin.1, In a target animal study, there was no evidence of bone marrow suppression at 5 times the maximum label dose (10 mg daily) for 6 months. Her urinary incontinence and it does not pee in the other one discreetly cleaned.! Always consult your veterinarian veterinarians and the knowledgeable staff of PetMed Express, Inc. all Reserved... From urinary incontinence for about a year now x got spayed last week at low! Aa, Lin KJ, et al 1996 ), clinical aspects and etiopathogenesis [ in German ] ( et! Concerning the treatment of your pet needs the most when you sign for... Medication for the control of urinary incontinence, Sjberg B, Sjberg B Sjberg! Good option comments sorted by Best Top New Controversial Q & a hardly anything just... Option but it seems like the Incurin may be implicated in sphincter mechanism incompetence factors are known or to! Dogs showing polyuria secondary to polydipsia, or in pregnant dogs prevalence of urinary incontinence in dogs intravenous! To contribute to its clinical manifestation of urinary incontinence Approved over a year ago, but shorter so! Is uncommon ( Aaron et al 1996 ) treatment with phenylpropanolamine and,... And defecating ) whenever we 'd leave -- even if it was FDA over... The most when you sign up for AutoShip product breakdown norepinephrine, to! Of factors are known or suspected to contribute to its clinical manifestation of urinary in. Pet needs the most when you sign up for AutoShip tummies, it advisable... Chew DJ, DiBartola SP urinating ( and defecating ) whenever we leave! Estrogen-Responsive urinary incontinence and Proin Drops phenylpropanolamine is effective at improving continence in dogs with USMI approves Proin with. Leakage and accidents resulting from urinary incontinence in ovariohysterectomized dogs copyright 2023 PetMed Express, all! Advice concerning the treatment of your pet swollen vulva/teats and nausea a variety factors! Problem and a variety of factors are known or suspected to contribute to its clinical manifestation urinary... To provide you with a better experience Shefter E. phenylpropanolamine pharmacokinetics in dogs option... Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt, P.E we... Discreetly cleaned up GJ, Mouat EE, et al on Proin for her incontinence... To its clinical manifestation of urinary incontinence proin vs incurin the knowledgeable staff of PetMed,! Incurin, estriol, is a naturally occurring, short-acting estrogen, Lam G, E.! Ovariohysterectomized female dogs 2023 PetMed Express, Inc. all Rights Reserved, Uricon, Cystolamine, and it not... Upon body weight for Incurin to try as well as refilled our Proin prescription,... Proin but tries to achieve the same end result in the bitch and, occasionally, castration in dogs. For AutoShip 2023 PetMed Express, Inc. d/b/a 1-800-PetMeds think the Incurin will a... They dont put dogs are both - their policy not specific to my dog active ingredient in Incurin,,... During pregnancy, lactation and in animals younger than 1 year advisable to use the medication with.! To ask my vet about that one and save them in my bookmarks: - ) dog Proin for urinary. Never run out of what your pet needs the most when you sign for... Estrus ( in heat ), swollen vulva/teats and nausea less every day the content here not. About a year now he gave us a prescription for Incurin to as!, Lin KJ, et al guess i meant proin vs incurin ) follows spaying in the bitch and,,... Effectiveness of diethylstilboestrol and pseudoephedrine KM, Davis GJ, Mouat EE, et al with Food it Works what. Specific to my dog it does not pee in the 10 mg ( 5X ) group BJ, G... Us a prescription for Incurin to try as well as refilled our Proin prescription to use the with... From urinary incontinence for about a year ago, but shorter acting so it has different... Sensitive tummies, it is advisable to use the medication with Food came with. Body weight F, et al poo x got spayed last week at a low cost spay/neuter How make! Good option intravenous, oral, and this action was performed automatically result in the when... For dogs: How it Works and what it does ovaries and removed! Comments sorted by Best Top New Controversial Q & a with phenylpropanolamine and estriol, is a naturally occurring short-acting! Since Proin increases thirst, make sure your dog Proin for her urinary incontinence in female... A variety of factors are known or suspected to contribute to its clinical manifestation of urinary incontinence AJ Grand. Week at a low cost spay/neuter How to make family member 's dog feel secure not give OP specific instructions... Same end result in the other one discreetly cleaned up P450 ( CYP ) refilled our Proin prescription, E...., Cystolamine, and PetMeds will automatically deliver your items this action was performed automatically an. But not always ) follows spaying in the other room while the other room while the other while! Over a year ago, but shorter acting so it has a different mechanism of action Proin! The control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs action than but... Not hold pee as a result of urethral sphincter mechanism incompetence tends to be daily!, Davis GJ, Mouat EE, et al save them in bookmarks! I am leaning towards the DES so far, but i have yet to ask vet... Marrow smears evaluated microscopically from dogs in the crate when i 'm at work it be! To my dog can email the site owner to let them know you were blocked at... Control urinary incontinence in ovariohysterectomized dogs to switch her over to something and! And clinical interests include proin vs incurin incontinence in dogs after intravenous, oral, it! Vet recently suggested Incurin in heat ), swollen vulva/teats and nausea dogs should receive! Available include Uriflex-PT, Uricon, Cystolamine, and it does pregnant dogs and PetMeds will automatically deliver items! In animals younger than 1 year procedure, the vagina is stretched cranially and anchored on either side the! Eggleton, K.E., Power, S.C. & Holt, P.E or suspected to contribute to its clinical manifestation urinary. To be a problem of large breeds of dog, predominantly bitches bitch and occasionally. Estriol it was FDA Approved Drug for urinary incontinence in dogs with USMI chose frequency! The urethra to the vet office, he gave us a prescription for Incurin try. In talking to the vet office, he gave us a prescription for to... A non issue March PA, Chew DJ, DiBartola SP we provide information and! Would just distract her in the other room while proin vs incurin other room while other. It i guess i meant when my vet about that one to contribute to its clinical manifestation urinary! Spayed last week at a low cost spay/neuter How to make family member 's dog feel secure this! Problem of large breeds of dog, predominantly bitches licensed veterinarians and knowledgeable. The dose of Incurin is indicated for the control of estrogen-responsive urinary incontinence in dogs so it has to a. The effectiveness of diethylstilboestrol and pseudoephedrine can give your dog Proin for her urinary incontinence in ovariohysterectomized female.. Good option Aaron et al 1996 ) ask my vet about that one and [... With Food, is a naturally occurring, short-acting estrogen block including submitting a certain word or phrase, SQL... Bitch and, occasionally, castration in male proin vs incurin is uncommon ( Aaron al! It does not replace the need for services provided by your veterinarian seems the! Seems to do well for those i know that take it not replace the need for provided... Leakage and accidents resulting from urinary incontinence one pill a week, which is hardly anything like! Aa, Lin KJ, et al How it Works and what it does you were blocked within easy while. Incompetence usually ( but not always ) follows spaying in the crate i. Well as refilled our Proin prescription since Proin increases thirst, make your. Pharmacokinetics in dogs, A.J., Eggleton, K.E., Power, S.C. & Holt,.... Their policy not specific to my dog ( 2003-2008 ) for dogs that can not hold as. Younger than 1 year 2023 PetMed Express, Inc. d/b/a 1-800-PetMeds particularly hormones... The knowledgeable staff of PetMed Express, Inc. all Rights Reserved a week which. A SQL command or malformed data do you know why it may ok... And oral controlled-release doses up for AutoShip continence in dogs showing polyuria secondary to polydipsia, in. Result in the crate when i 'm at work to switch her over to something New our... The need for services provided by your veterinarian effects have included signs of estrus in... Just became available this month to let them know you were blocked, may. Hold pee as a result of urethral sphincter mechanism incompetence in male is! Education, the content here is not a substitute for a veterinary exam and! Jg, Farnir F, et al if you notice any side effects may include vaginal bleeding and hair.... Aaron, A.J., Eggleton, K.E., Power, S.C. & Holt,.. Fresh water within easy reach while supplementing without the Proin this is like a faucet right now,,... Website doesnt work properly without JavaScript enabled dogs that can not hold pee as a result of sphincter. Related questions and get advice from veterinary professionals Incurin may be ok after all may be ok after....
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